Medication CBD oil can interact with: this is what you need to know - Dutch Natural Healing

Can CBD oil interact with medications?

Jan 26, 2026Marieke van Haaster

CBD oil is increasingly used by people looking for natural support for aches, physical discomfort, or reduced overall health. At the same time, many people in this group take daily medications. This raises a logical and important question: can CBD oil interact with medications?

The answer is: yes, CBD oil can interact with certain medications.

Not for everyone and not in every situation, but it is something to take seriously. In this blog, you will read how CBD and medications can influence each other, what to watch for, and when extra caution is wise.

Why CBD and medications require attention together

Many people combine supplements with prescribed medication. CBD is often seen as natural and mild, but that does not automatically mean it cannot affect processes in the body.

Especially people who take daily medication for pain, inflammation, or a chronic health condition should consider the combination of medication and CBD carefully. Not to avoid its use, but to make informed choices.

What happens to CBD in the body?

Absorption and processing of CBD

When you use CBD, for example in the form of CBD oil, cannabidiol is absorbed through the mucous membranes or via the digestive system. After that, it reaches the liver.

CBD inhibits the cytochrome P450 enzyme system in the liver. This same system is also involved in the breakdown of many medications.

Why this matters with medication

CBD can temporarily influence these enzymes. As a result, certain medications may be broken down more slowly. This can mean that a medication remains active in the body longer than intended.

This does not necessarily cause problems, but it may affect:

  • How strongly a medication is experienced,

  • How long the medication works,

  • The risk of side effects.

That is why people often speak about a potential interaction with medications.

Medications where extra awareness is wise

Not every combination is the same. Still, there are three groups of medications where people most often have questions about combining them with CBD.

Pain relief and anti-inflammatory drugs

People with physical complaints often use painkillers or anti-inflammatory medication. At the same time, some choose natural support, for example through products from the collection CBD for pain.

CBD may influence how the body processes these medications. This does not mean they cannot be used together, but it does mean it is wise to stay alert to changes in effect or how you feel.

Medication for stress and tension

For stress-related complaints or tension, some people use medication that affects the nervous system. CBD is also used in this context.

When both are combined, relaxation may sometimes be experienced more strongly. This requires mindful dosing and listening carefully to the body.

An example includes calming medications such as diazepam and lorazepam. These drugs suppress the nervous system. CBD may enhance their effects, which can lead to drowsiness or reduced alertness.

Sleep medication

Some people combine CBD with sleep medication, for example because they have trouble staying asleep. In this case, extra caution is important, especially with products aimed at rest and relaxation such as CBD for sleep.

CBD can support feelings of relaxation, but in combination with sleep aids, this effect may feel stronger.

Does this mean CBD cannot be used with medications?

No, it does not. Many people use CBD alongside medication without issues. The difference often depends on:

  • The CBD dosage,

  • The type of medication,

  • Overall health,

  • Individual sensitivity.

The combination of medication and CBD mainly requires awareness and personalization.

What can you keep in mind yourself?

Start with a low dose

Many people choose to start low and build up slowly. This is especially important if you already take medication. It gives the body time to respond.

Pay attention to signals from your body

Does the effect of your medication change? Do you feel different than usual? These are signals to take seriously. Sometimes adjusting the dosage or taking a short break is enough.

Choose a suitable form

Not everyone wants to take extra oil alongside medication. In that case, some people choose alternatives such as CBD capsules, which are easier to dose, or CBD patches, which work gradually and do not involve the digestive system.

Consult when in doubt

Although CBD is freely available, consulting a doctor or pharmacist remains wise if you use medication, especially with fragile health or multiple medications at once.

The goal is not to replace medication, but to seek support without unnecessary risks.

CBD as part of conscious self-care

For many people with aches or physical discomfort, CBD is not a quick fix but part of a broader approach to health. This means listening to the body, taking dosages seriously, and making choices that fit the personal situation.

CBD and medications do not have to exclude each other, as long as the use is approached with care and realistic expectations. When in doubt, always contact customer service or your doctor.

Sources

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Marieke van Haaster

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Marieke van Haaster, MSc is a health scientist with over 20 years of experience in cannabis research. She worked as head of R&D at MariPharm and conducted clinical studies for various pharmaceutical companies. Since 2022, she has been an independent researcher and advisor in the field of cannabis and cannabinoids. For Dutch Natural Healing, she shares scientifically substantiated insights into the effects and applications of cannabis products.

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